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Learn About GLP-1 Weight Loss

Expert guides and resources to help you understand GLP-1 medications, what to expect, and how to achieve the best results.

GLP-1 Medication Comparison

Compare FDA-approved weight loss medications side-by-side. All data sourced from clinical trials and FDA documentation.

MedicationBrand NamesMonthly CostAverage Weight LossFrequencyFDA Approved
Tirzepatide
Dual GIP/GLP-1 receptor agonist
Mounjaro, Zepbound
$550 - $999
20%
Once weekly
Semaglutide
GLP-1 receptor agonist
Ozempic, Wegovy, Rybelsus
$250 - $599
15%
Once weekly
Compounded Semaglutide
GLP-1 receptor agonist (compounded)
Various compounding pharmacies
$199 - $399
12%
Once weekly
Liraglutide
GLP-1 receptor agonist
Saxenda, Victoza
$1200 - $1500
8%
Once daily

Tirzepatide

Tirzepatide is a first-in-class dual GIP/GLP-1 receptor agonist. Approved as Zepbound for weight management in 2023, it has shown superior weight loss results compared to single-action GLP-1 medications.

Typical Dose
5-15 mg once weekly
Administration
Subcutaneous injection
Average Weight Loss
20%
Key Benefits
  • Up to 22.5% average weight loss
  • Dual-action mechanism
  • FDA approved for weight management

Semaglutide

Semaglutide is a GLP-1 receptor agonist FDA-approved for chronic weight management. Originally developed for type 2 diabetes treatment (Ozempic), the higher-dose version (Wegovy) received FDA approval for weight loss in 2021.

Typical Dose
2.4 mg once weekly (Wegovy)
Administration
Subcutaneous injection
Average Weight Loss
15%
Key Benefits
  • 15-20% average weight loss
  • Once-weekly dosing
  • FDA approved for chronic weight management

Compounded Semaglutide

Compounded semaglutide is a pharmacy-prepared version of semaglutide available at lower cost. While containing the same active ingredient, it is not FDA-approved and may vary in quality and efficacy between compounding pharmacies.

Typical Dose
2.4 mg once weekly
Administration
Subcutaneous injection
Average Weight Loss
12%
Key Benefits
  • Lower cost alternative
  • Same active ingredient
  • Once-weekly dosing

Important Medical Information

  • • All GLP-1 medications require a prescription from a licensed healthcare provider
  • • Individual results vary based on dosage, lifestyle factors, and medical history
  • • Common side effects include nausea, diarrhea, and constipation, typically mild and temporary
  • • Not suitable for people with certain medical conditions including thyroid cancer history
  • • Always consult with a healthcare provider before starting any weight loss medication

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