Tirzepatide vs Semaglutide: Which GLP-1 is Right for You?

Comparing the Two Leading GLP-1 Medications

Both tirzepatide (Mounjaro/Zepbound) and semaglutide (Wegovy/Ozempic) have emerged as powerful tools in the fight against obesity. But how do they compare?

Mechanism of Action

**Semaglutide** is a GLP-1 receptor agonist that mimics a single gut hormone.

**Tirzepatide** is a dual GIP/GLP-1 receptor agonist, targeting two gut hormones simultaneously.

Weight Loss Results

Clinical trials show impressive results for both:

**Semaglutide (STEP trials):**

**Tirzepatide (SURMOUNT trials):**

Side Effect Profiles

Both medications share similar side effects:

Tirzepatide may have slightly higher rates of GI side effects initially.

Cost Comparison

Without insurance, both medications are similarly priced at $1,000-1,500/month. However, compounded versions may be available at lower costs through qualified clinics.

Making Your Choice

The best medication depends on your individual health profile, goals, and response to treatment. Many patients who plateau on semaglutide have found success switching to tirzepatide.

Consult with a medical weight loss specialist to determine the optimal choice for your situation.